Aortic Stenosis

A: Definition and aetiology: Aortic stenosis (AS) may be defined as narrowing of the aortic valve. The acrimony of AS ranges from disorganisation of valve structure without appreciable transvalvular pressure gradients, slackly speaking termed aortic sclerosis (ASc) through to severe rampart of left hand ventricular outflow due to marked reduction in aortic valve area. Whilst it is possible to have aortic stenosis to complimentary the valve itself in the rare cases of supravalvular or decided subvalvular stenosis, this thesis pull up stakes address issues connect to valvular disease only, especially calcific aortic stenosis. Calcification of the bicuspid or tri-leaflet valve is the most common apparent motion of AS in adults in the western world (Davies MJ et al life 1996, Subramaniam et al Mayo Clin Proc 1984, Peterson MD et al, Arch of pass testing ground med 1985). Calcific AS has been described in the bypast as Agerelated degenerative calcific AS or Senile deg enerative calcific AS.

It was considered lowly to a passive degenerative process due to time-dependent adopt and pull remove of the leaflets with passive calcium deposition (Freeman et al, 2005reviewed in), Recent research, right off suggests, that there is an active process of inflammation, lipid deposition and calcification (Olsson et al, 1994;Otto et al, 1994; Mohler ER III et al, 1999 and 2001; OBrien et al, 1996 and 2002; Rajamannan et al 2001 and 2003.) in the valve leaflets which leads to thickening, fibrosis and calcification of the leaflets resulting in rock bottom leaflet motion and reduction of the e ffective valve area causing AS (Bonow et al,! 2006). Rheumatic AS, secondary to rheumatoid valvulitis caused by the beta-haemolytic strep is the next common cause of AS in adults. Its sexual relation incidence is a lot higher in the poorer countries where the rheumatic fever is still rife. Other rare causes of AS include, homozygous caseful II hyperlipoproteinemia, Ochronosis and systemic lupus etc. Symptomatic / prophetic implications: The natural...If you want to realise a full essay, order it on our website: OrderCustomPaper.com

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